Transcriptomic meta-analysis reveals unannotated long non-coding RNAs related to the immune response in sheep.

ABSTRACT: Long non-coding RNAs (lncRNAs) are involved in several biological processes, including the immune system response to pathogens and vaccines. The annotation and functional characterization of lncRNAs is more advanced in humans than in livestock species. Here, we take advantage of the increasing number of high-throughput functional experiments deposited in public databases in order to uniformly analyse, profile unannotated lncRNAs and integrate 422 ovine RNA-seq samples from the ovine immune system. We identified 12302 unannotated lncRNA genes with support from independent CAGE-seq and histone modification ChIP-seq assays. Unannotated lncRNAs showed low expression levels and sequence conservation across other mammal species. There were differences in expression levels depending on the genomi

SUBMITTER: Bilbao-Arribas M 

PROVIDER: S-EPMC9725098 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature