Exploring the mono-/bistability range of positively autoregulated signaling systems in the presence of competing transcription factor binding sites.

ABSTRACT: Binding of transcription factor (TF) proteins to regulatory DNA sites is key to accurate control of gene expression in response to environmental stimuli. Theoretical modeling of transcription regulation is often focused on a limited set of genes of interest, while binding of the TF to other genomic sites is seldom considered. The total number of TF binding sites (TFBSs) affects the availability of TF protein molecules and sequestration of a TF by TFBSs can promote bistability. For many signaling systems where a graded response is desirable for continuous control over the input range, biochemical parameters of the regulatory proteins need be tuned to avoid bistability. Here we analyze the mono-/bistable parameter range for positively autoregulated two-component systems (TCSs) in the presenc

SUBMITTER: Gao R 

PROVIDER: S-EPMC9725139 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature