Mass spectrometry-based identification of new serum biomarkers in patients with latent infection pulmonary tuberculosis.

ABSTRACT: Noninvasive and simple indicators for diagnosing latent tuberculosis (TB) infection (LTBI) and tracking progression from latent infection to active TB infection are still desperately needed. The aim of this study was to screen and identify possible biomarkers for diagnosing LTBI and monitoring the progression from latent infection to active TB infection, as well as to investigate the underlying processes and functions. To assess changes in metabolite composition associated with active tuberculosis infection in humans, whole blood supernatants were collected from patients with LTBI, drug-susceptible TB patients, drug-resistant TB patients, and healthy controls. The metabolites in all serum samples were extracted by oscillatory, deproteinization, and then detected by liquid chromatography-ta

SUBMITTER: Li YX 

PROVIDER: S-EPMC9726300 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature