Construction of ceRNA network and key gene screening in cervical squamous intraepithelial lesions.

ABSTRACT:

Background

This study aimed to construct an endogenous competition network for cervical squamous intraepithelial lesions using differential gene screening.

Methods

GSE149763 was used to screen differentially expressed long non-coding RNAs (lncRNAs) and mRNAs to predict correlated microRNAs (miRNAs). The correlated miRNAs and GSE105409 were used to screen differentially expressed miRNAs for differential co-expression analysis, and the co-expressed differentially expressed miRNAs were used to predict correlated mRNAs. Differentially expressed mRNAs, miRNAs, and lncRNAs were visualized, and differential gene screening, enrichment, and pathway analysis were performed.

Results

The ceRNA network of cervical squamous intraepithelial was successfully established and a potenti

SUBMITTER: Qi D 

PROVIDER: S-EPMC9726336 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature