Analysis of the potential molecular biology of triptolide in the treatment of diabetic nephropathy: A narrative review.

ABSTRACT:

Objective

To explore the potential mechanism of triptolide in diabetic nephropathy (DN) treatment using network pharmacology.

Methods

The main targets of triptolide were screened using the TCMSP, DrugBank, and NCBI databases, and gene targets of DN were searched using the DrugBank, DisGeNET, TTD, and OMIM databases. All of the above targets were normalized using the UniProt database to obtain the co-acting genes. The co-acting genes were uploaded to the STRING platform to build a protein-protein interaction network and screen the core acting targets. Gene ontology and Kyoto encyclopedia of genes and genomes analyses of the core targets were performed using Metascape. Molecular docking validation of triptolide with the co-acting genes was performed using the Swiss Dock platfo

SUBMITTER: Gao Y 

PROVIDER: S-EPMC9726356 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature