Dataset Information

Characteristics of antifungal utilization for hospitalized children in the United States.

ABSTRACT:

Objective

To characterize antifungal prescribing patterns, including the indication for antifungal use, in hospitalized children across the United States.

Design

We analyzed antifungal prescribing data from 32 hospitals that participated in the SHARPS Antibiotic Resistance, Prescribing, and Efficacy among Children (SHARPEC) study, a cross-sectional point-prevalence survey conducted between June 2016 and December 2017.

Methods

Inpatients aged <18 years with an active systemic antifungal order were included in the analysis. We classified antifungal prescribing by indication (ie, prophylaxis, empiric, targeted), and we compared the proportion of patients in each category based on patient and antifungal characteristics.

Results

Among 34,927 surveyed patients, 2,095 (6%) received at least 1 systemic antifungal and there were 2,207 antifungal prescriptions. Most patients had an underlying oncology or bone marrow transplant diagnosis (57%) or were premature (13%). The most prescribed antifungal was fluconazole (48%) and the most common indication for antifungal use was prophylaxis (64%). Of 2,095 patients receiving antifungals, 79 (4%) were prescribed >1 antifungal, most often as targeted therapy (48%). The antifungal prescribing rate ranged from 13.6 to 131.2 antifungals per 1,000 patients across hospitals (P < .001).

Conclusions

Most antifungal use in hospitalized children was for prophylaxis, and the rate of antifungal prescribing varied significantly across hospitals. Potential targets for antifungal stewardship efforts include high-risk, high-utilization populations, such as oncology and bone marrow transplant patients, and specific patterns of utilization, including prophylactic and combination antifungal therapy.

SUBMITTER: Eguiguren L

PROVIDER: S-EPMC9726632 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Characteristics of antifungal utilization for hospitalized children in the United States.

Eguiguren Lourdes L Lee Brian R BR Newland Jason G JG Kronman Matthew P MP Hersh Adam L AL Gerber Jeffrey S JS Lee Grace M GM Schwenk Hayden T HT

Antimicrobial stewardship & healthcare epidemiology : ASHE 20221202 1

<h4>Objective</h4>To characterize antifungal prescribing patterns, including the indication for antifungal use, in hospitalized children across the United States.<h4>Design</h4>We analyzed antifungal prescribing data from 32 hospitals that participated in the SHARPS Antibiotic Resistance, Prescribing, and Efficacy among Children (SHARPEC) study, a cross-sectional point-prevalence survey conducted between June 2016 and December 2017.<h4>Methods</h4>Inpatients aged <18 years with an active systemi ...[more]

PMID: 36505943

Similar Datasets

Project description:ImportanceTelehealth services, which allow patients to communicate with a remotely located clinician, are increasingly available; however, prevalence of telehealth use, including videoconferencing visits, remains unclear.ObjectiveTo measure the use of and willingness to use telehealth modalities across the US population.Design, setting, and participantsThis survey study, conducted between February 2019 and April 2019, asked participants about their use of different telehealth modalities, reasons for not using videoconferencing visits, and willingness to use videoconferencing visits. Questions were continuously posed to panel members and closed after 2555 responses were obtained, at which point 3932 panel members had been invited, for a 65.0% response rate.ExposuresDemographic characteristics (ie, age, sex, race, rural/urban residency, education level, and income).Main outcomes and measuresSelf-reported use of specific telehealth modalities, reasons for nonuse, and willingness to use videoconferencing in the future.ResultsA total of 2555 individuals completed the survey with a mean (SD) age of 57.2 (14.2) years; 1453 respondents (weighted percentage, 51.9%) were women, and 2043 (weighted percentage, 73.4%) were White individuals. Overall, 1343 respondents (weighted percentage, 50.8%) reported use of a nontelephone telehealth modality, ranging from 873 respondents (weighted percentage, 31.9%) for patient portals and 89 respondents (weighted percentage, 4.2%) for videoconferencing visits. Although 1309 respondents (weighted percentage, 49.2%) overall answered that they were willing or very willing to use videoconferencing visits, respondents who were Black individuals (OR, 0.58; 95% CI, 0.38-0.91), aged older than 65 years (OR, 0.51; 95% CI, 0.40-0.66), or had less education (high school or less vs advanced degrees: OR, 0.37; 95% CI, 0.25-0.56) were less likely to express willingness.Conclusions and relevanceDespite the focused policy attention on videoconferencing visits, the results of this survey study suggest that other forms of telehealth were more dominant prior to 2020. Targeted efforts may be necessary for videoconferencing visits to reach patient groups who are older or have less education, and payer policies supporting other forms of telemedicine may be appropriate to enhance access.

Dataset Information

Characteristics of antifungal utilization for hospitalized children in the United States.

Objective

Design

Methods

Results

Conclusions

Publications

Characteristics of antifungal utilization for hospitalized children in the United States.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets