Sex-specific roles of hippocampal microRNAs in stress vulnerability and resilience.

ABSTRACT: Contrary to intuition, most individuals are resilient to psychological trauma and only a minority is vulnerable. Men and women are known to respond differently to trauma exposure, however, mechanisms underlying the relationship between sex differences and trauma resilience and vulnerability are not yet fully understood. Taking advantage of the Behavioral Profiling approach, which enables differentiating between 'affected' and 'unaffected' individuals, we examined sex-associated differences in stress exposure effects on hippocampal expression of selected stress-related GABA-A receptor targeting miRNAs. Levels of the miRNA-144 and miRNA-33 were measured in male and female affected (vulnerable, e.g., higher freezing time) and unaffected (resilient) rats. In male rats, increased levels of miRN

SUBMITTER: Krispil-Alon M 

PROVIDER: S-EPMC9726879 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature