N7-methylguanosine methylation-related regulator genes as biological markers in predicting prognosis for melanoma.

ABSTRACT: The aim of this study is to find those N7-methylguanosine (m7G) methylation-related regulator genes (m7GMRRGs) which were associated with melanoma prognosis and use them to develop a prognostic prediction model. Clinical information was retrieved online from The Cancer Gene Atlas (TCGA) and the Gene Expression Omnibus (GEO). R software was used to extract m⁷GMRRGs by differential expression analysis. To create a prognostic risk model, univariate and multivariate Cox regression analyses were employed for the evaluation of the prognostic significance of m⁷G methylation modifiers. Internal validation using cohort from TCGA (training set) and external validation using cohort from GEO (validation set) of the model were carried out. The model's predictive performance was co

SUBMITTER: Deng J 

PROVIDER: S-EPMC9726938 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature