Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology.

ABSTRACT:

Background

Conventional preclinical models often miss drug toxicities, meaning the harm these drugs pose to humans is only realized in clinical trials or when they make it to market. This has caused the pharmaceutical industry to waste considerable time and resources developing drugs destined to fail. Organ-on-a-Chip technology has the potential improve success in drug development pipelines, as it can recapitulate organ-level pathophysiology and clinical responses; however, systematic and quantitative evaluations of Organ-Chips' predictive value have not yet been reported.

Methods

870 Liver-Chips were analyzed to determine their ability to predict drug-induced liver injury caused by small molecules identified as benchmarks by the Innovation and Quality consortium, who has pu

SUBMITTER: Ewart L 

PROVIDER: S-EPMC9727064 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature