The long-term effect of biologics in patients with ulcerative colitis emerging from a large Japanese cohort.

ABSTRACT: To gain a better understanding of the effects of biologics, we evaluated clinical outcomes in patients with moderate to severe exacerbations of ulcerative colitis (UC). This retrospective, multicenter study retrieved the entire clinical courses of UC patients who began treatments between 2004 and 2018. All exacerbations and clinical parameters, including treatment details for exacerbations and both remission and re-exacerbation dates, were identified during the observation period. Two different endpoints, the cumulative incidence rates of surgical resection and re-exacerbation, were evaluated separately in moderate to severe exacerbation events. Among 1401 patients, 1626 exacerbation events were determined according to a partial Mayo score (remission: < 2, mild: 2-4, moderate: 5-7, and sev

SUBMITTER: Yokoyama Y 

PROVIDER: S-EPMC9727107 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature