Deep learning magnetic resonance imaging predicts platinum sensitivity in patients with epithelial ovarian cancer.

ABSTRACT:

Objective

The aim of the study is to develop and validate a deep learning model to predict the platinum sensitivity of patients with epithelial ovarian cancer (EOC) based on contrast-enhanced magnetic resonance imaging (MRI).

Methods

In this retrospective study, 93 patients with EOC who received platinum-based chemotherapy (≥4 cycles) and debulking surgery at the Sun Yat-sen Memorial Hospital from January 2011 to January 2020 were enrolled and randomly assigned to the training and validation cohorts (2:1). Two different models were built based on either the primary tumor or whole volume of the abdomen as the volume of interest (VOI) within the same cohorts, and then a pre-trained convolutional neural network Med3D (Resnet 10 version) was transferred to automatically extract

SUBMITTER: Lei R 

PROVIDER: S-EPMC9727155 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature