Analysis of DNMT1 gene variants in progression of neural tube defects-an in silico to in vitro approach.

ABSTRACT: Neural tube defects (NTDs) are significant congenital deformities of the central nervous system among which spina bifida is the most common form that occurs due to defect in the neurulation process of embryogenesis. NTDs are among the most common type of birth defects occurring at a range of 0.5-10 in every 1000 live births worldwide and are thought to have multifactorial etiology, including multigenetic and epigenetic notions. Epigenetic regulations control differential gene expression in normal and disease phenotypes. DNA methylation is a significant epigenetic process, guided by DNMT1, one of the most important maintenance methylating agents. However, the relationship between DNMT1 and NTDs had always been inconclusive and poorly understood. In the present study, by utilizing in silico

SUBMITTER: Sadhukhan S 

PROVIDER: S-EPMC9727204 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature