IL-33 induces granzyme C expression in murine mast cells via an MSK1/2-CREB-dependent pathway.

ABSTRACT: Granzymes comprise a group of proteases involved in the killing of infected or cancerous cells by the immune system. Although best studied in T cells and natural killer (NK) cells, they are also expressed in some innate immune cells. Granzymes B and C are encoded in the mouse chymase locus that also encodes a number of mast cell-specific proteases. In line with this, mast cells can express granzyme B, although how this is regulated and their ability to express other granzymes is less well studied. We therefore examined how IL-33, a cytokine able to activate mast cells but not induce degranulation, regulated granzyme B and C levels in mast cells. Granzyme C, but not B, mRNA was strongly up-regulated in bone marrow-derived mast cells following IL-33 stimulation and there was a corresponding

SUBMITTER: Phair IR 

PROVIDER: S-EPMC9727205 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature