Synthetic study toward the diterpenoid aberrarone.

ABSTRACT: An approach to aberrarone, an antimalarial diterpenoid natural product with tetracyclic skeleton is reported. Key to the stereoselective preparation of the 6-5-5 tricyclic skeleton includes the mediation of Nagata reagent for constructing the C1 all-carbon quaternary centers and gold-catalyzed cyclopentenone synthesis through C-H insertion.

SUBMITTER: Shi L 

PROVIDER: S-EPMC9727272 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature