Combined cell-based therapy strategies for the treatment of Parkinson's disease: focus on mesenchymal stromal cells.

ABSTRACT: Parkinson's disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia nigra. Levodopa is an effective and well-tolerated dopamine replacement agent. However, levodopa provides only symptomatic improvements, without affecting the underlying pathology, and is associated with side effects after long-term use. Cell-based replacement is a promising strategy that offers the possibility to replace lost neurons in Parkinson's disease treatment. Clinical studies of transplantation of human fetal ventral mesencephalic tissue have provided evidence that the grafted dopaminergic neurons can reinnervate the striatum, release dopamine, integrate into the host neural circuits, and improve motor functions. One of the

SUBMITTER: Rodriguez-Pallares J 

PROVIDER: S-EPMC9727452 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature