LncRNA ZFAS1 contributes to osteosarcoma progression via miR-520b and miR-520e-mediated inhibition of RHOC signaling

ABSTRACT: Highlights • Lnc-ZFAS1 is highly expressed in osteosarcoma.• Lnc-ZFAS1 could promote cell proliferation, migration, invasion and EMT in vitro.• Lnc-ZFAS1 acted sponger of miR-520b and miR-520e to promote RHOC.

Objectives

We examined the expression of Lnc-ZFAS1 in osteosarcoma and comprehensively evaluated its effects on osteosarcoma in vitro and vivo. Moreover, we revealed the regulatory mechanism between Lnc-ZFAS1 and miR-520b/miR-520e-mediated RHOC and provided a novel clue for ameliorating osteosarcoma.

Method

The expression of Long non-coding RNA Zinc Finger Antisense 1 (LncRNA ZFAS1) osteosarcoma tissues and normal tissues in the TCGA database was analyzed. Then, LncRNA ZFAS1 expression was further verified in clinical samples and osteosarcoma cell lines (U2OS and KH

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PROVIDER: S-EPMC9727593 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature