RAS inhibition and sepsis-associated acute kidney injury.

ABSTRACT:

Purpose

To evaluate the effect of renin-angiotensin system (RAS) inhibiting medications prior to admission on the severity of kidney injury in patients presenting with sepsis-associated acute kidney injury (SA-AKI).

Materials and methods

A single center, retrospective cohort study of critically ill adult patients admitted with diagnoses of both sepsis and AKI. RAS inhibition was defined as angiotensin converting enzyme inhibitors or angiotensin receptor blockers. The primary outcome was Kidney Disease: Improving Global Outcomes stage AKI upon hospital admission.

Results

Of 707 individuals studied, patients receiving RAS inhibition prior to admission (vs. those not) had more stage 3 AKI (40.1% vs. 28.7%; p = 0.008) and more frequently reached stage 3 AKI during the fir

SUBMITTER: Flannery AH 

PROVIDER: S-EPMC9727727 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature