Liposomal Binuclear Ir(III)-Cu(II) Coordination Compounds with Phosphino-Fluoroquinolone Conjugates for Human Prostate Carcinoma Treatment.

ABSTRACT: Novel heteronuclear Ir^III-Cu^II coordination compounds ([Ir(η⁵-Cp*)Cl₂Pcfx-Cu(phen)](NO₃)·1.75(CH₃OH)·0.75(H₂O) (1), [Ir(η⁵-Cp*)Cl₂Pnfx-Cu(phen)](NO₃)·1.75(CH₃OH)·0.75(H₂O) (2), [Ir(η⁵-Cp*)Cl₂Plfx-Cu(phen)](NO₃)·1.3(H₂O)·1.95(CH₃OH) (3), [Ir(η⁵-Cp*)Cl₂Psfx-Cu(phen)] (4)) bearing phosphines derived from fluoroquinolones, namely, sparfloxacin (Hsfx), ciprofloxacin (Hcfx), lomefloxacin (Hlfx), and norfloxacin (Hnfx), have been synthesized and studied as possible anticancer chemotherapeutics. All compounds have been characterized by electrospray ionization mass

SUBMITTER: Komarnicka UK 

PROVIDER: S-EPMC9727733 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature