Newfound features of meiotic chromosome organization that promote efficient congression and segregation in Caenorhabditis elegans oocytes.

ABSTRACT: Although end-on microtubule-kinetochore attachments typically drive chromosome alignment, Caenorhabditis elegans oocytes do not form these connections. Instead, microtubule bundles run laterally alongside chromosomes and a ring-shaped protein complex facilitates congression (the "ring complex", RC). Here, we report new aspects of RC and chromosome structure that are required for congression and segregation. First, we found that in addition to encircling the outside of each homologous chromosome pair (bivalent), the RC also forms internal subloops that wrap around the domains where cohesion is lost during the first meiotic division; cohesin removal could therefore disengage these subloops in anaphase, enabling RC removal from chromosomes. Additionally, we discovered new features of c

SUBMITTER: Horton HH 

PROVIDER: S-EPMC9727786 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature