Dishevelled controls bulk cadherin dynamics and the stability of individual cadherin clusters during convergent extension.

ABSTRACT: Animals are shaped through the movement of large cellular collectives. Such morphogenetic processes require cadherin-based cell adhesion to maintain tissue cohesion and planar cell polarity to coordinate movement. Despite a vast literature surrounding cadherin-based adhesion and planar cell polarity, it is unclear how these molecular networks interface. Here we investigate the relationship between cadherins and planar cell polarity during gastrulation cell movements in Xenopus laevis. We first assessed bulk cadherin localization and found that cadherins were enriched at a specific subset of morphogenetically active cell-cell junctions. We then found that cadherin and actin had coupled temporal dynamics and that disruption of planar cell polarity uncoupled these dynamics. Next, using

SUBMITTER: Huebner RJ 

PROVIDER: S-EPMC9727802 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature