Efficacy and safety of remimazolam for non-obese patients during anesthetic induction in cardiac surgery: study protocol for a multicenter randomized trial.

ABSTRACT:

Background

Valvular heart disease remains common in both developed and developing countries, and it requires timely surgical treatment when necessary. However, the stability of hemodynamics during anesthesia induction in patients undergoing valve replacement surgery is difficult to maintain due to their impaired cardiac function. Remimazolam, a novel and ultrashort-acting intravenous sedative-hypnotic, may be beneficial to stable hemodynamics, but the evidence is limited. Therefore, this study aims to evaluate the effect of remimazolam induction on hemodynamics compared with midazolam and etomidate in patients undergoing valve replacement surgery.

Methods

This is a prospective, multicenter randomized controlled trial (RCT). Three hundred and sixty-three non-obese adult patie

SUBMITTER: Yu H 

PROVIDER: S-EPMC9727858 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature