Potential therapeutic strategies for photoreceptor degeneration: the path to restore vision.

ABSTRACT: Photoreceptors (PRs), as the most abundant and light-sensing cells of the neuroretina, are responsible for converting light into electrical signals that can be interpreted by the brain. PR degeneration, including morphological and functional impairment of these cells, causes significant diminution of the retina's ability to detect light, with consequent loss of vision. Recent findings in ocular regenerative medicine have opened promising avenues to apply neuroprotective therapy, gene therapy, cell replacement therapy, and visual prostheses to the challenge of restoring vision. However, successful visual restoration in the clinical setting requires application of these therapeutic approaches at the appropriate stage of the retinal degeneration. In this review, firstly, we discuss the mechan

SUBMITTER: Karamali F 

PROVIDER: S-EPMC9727916 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature