Construction and validation of prognostic signature for hepatocellular carcinoma basing on hepatitis B virus related specific genes.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a frequent primary liver cancer, and it is one of the leading cause of cancer-related deaths. Hepatitis B virus (HBV) infection is a crucial risk factor for HCC. Thus, this study aimed to explore the prognostic role of HBV-positive HCC related specific genes in HCC.

Methods

The HCC related data were downloaded from three databases, including The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), and Gene Expression Omnibus (GEO). Univariate Cox regression analysis and LASSO Cox regression analysis were conducted to build the Risk score. Multivariate Cox regression analysis and survival analysis determined the independent prognostic indicators.

Results

After cross analysis of differentially expressed

SUBMITTER: Wang L 

PROVIDER: S-EPMC9727957 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature