Analysis of multiple-period group randomized trials: random coefficients model or repeated measures ANOVA?

ABSTRACT:

Background

Multiple-period parallel group randomized trials (GRTs) analyzed with linear mixed models can represent time in mean models as continuous or categorical. If time is continuous, random effects are traditionally group- and member-level deviations from condition-specific slopes and intercepts and are referred to as random coefficients (RC) analytic models. If time is categorical, random effects are traditionally group- and member-level deviations from time-specific condition means and are referred to as repeated measures ANOVA (RM-ANOVA) analytic models. Longstanding guidance recommends the use of RC over RM-ANOVA for parallel GRTs with more than two periods because RC exhibited nominal type I error rates for both time parameterizations while RM-ANOVA exhibited inflated typ

SUBMITTER: Moyer JC 

PROVIDER: S-EPMC9727985 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature