Comparative genomics of Campylobacter jejuni from clinical campylobacteriosis stool specimens.

ABSTRACT:

Background

Campylobacter jejuni is a pervasive pathogen of major public health concern with a complex ecology requiring accurate and informative approaches to define pathogen diversity during outbreak investigations. Source attribution analysis may be confounded if the genetic diversity of a C. jejuni population is not adequately captured in a single specimen. The aim of this study was to determine the genomic diversity of C. jejuni within individual stool specimens from four campylobacteriosis patients. Direct plating and pre-culture filtration of one stool specimen per patient was used to culture multiple isolates per stool specimen. Whole genome sequencing and pangenome level analysis were used to investigate genomic diversity of C. jejuni within a patient.

Results

A tota

SUBMITTER: Djeghout B 

PROVIDER: S-EPMC9727990 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature