Anesthetics to Prevent Lung Injury in Cardiac Surgery: A Randomized Controlled Trial.

ABSTRACT:

Objectives

To investigate if sevoflurane based anesthesia is superior to propofol in preventing lung inflammation and preventing postoperative pulmonary complications.

Design

Randomized controlled trial.

Setting

Single tertiary care university hospital.

Participants

Forty adults undergoing cardiac surgery with cardiopulmonary bypass.

Interventions

Patients were randomized in a 1:1 ratio to anesthetic maintenance with sevoflurane or propofol.

Measurements and main results

Blood and bronchoalveolar lavage fluid was sampled before and after bypass to measure pulmonary inflammation using a biomarker panel. The change in bronchoalveolar lavage concentration of tumor necrosis factor alpha (TNFα) was the primary outcome. Secondary outcomes included lung

SUBMITTER: O'Gara BP 

PROVIDER: S-EPMC9728032 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature