Association of Time to Clinical Remission With Sustained Resolution in Children With New-Onset Infantile Spasms.

ABSTRACT:

Background and objectives

Standard therapies (adrenocorticotropic hormone [ACTH], oral steroids, or vigabatrin) fail to control infantile spasms in almost half of children. Early identification of nonresponders could enable rapid initiation of sequential therapy. We aimed to determine the time to clinical remission after appropriate infantile spasms treatment initiation and identify predictors of the time to infantile spasms treatment response.

Methods

The National Infantile Spasms Consortium prospectively followed children aged 2-24 months with new-onset infantile spasms at 23 US centers (2012-2018). We included children treated with standard therapy (ACTH, oral steroids, or vigabatrin). Sustained treatment response was defined as having the last clinically recognized infan

SUBMITTER: Yuskaitis CJ 

PROVIDER: S-EPMC9728034 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature