Host acid signal controls Salmonella flagella biogenesis through CadC-YdiV axis.

ABSTRACT: Upon entering host cells, Salmonella quickly turns off flagella biogenesis to avoid recognition by the host immune system. However, it is not clear which host signal(s) Salmonella senses to initiate flagellum control. Here, we demonstrate that the acid signal can suppress flagella synthesis and motility of Salmonella, and this occurs after the transcription of master flagellar gene flhDC and depends on the anti-FlhDC factor YdiV. YdiV expression is activated after acid treatment. A global screen with ydiV promoter DNA and total protein from acid-treated Salmonella revealed a novel regulator of YdiV, the acid-related transcription factor CadC. Further studies showed that CadC_C, the DNA binding domain of CadC, directly binds to a 33 nt reg

SUBMITTER: Wang W 

PROVIDER: S-EPMC9728131 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature