Characterization of immune microenvironment infiltration and m⁶A regulator-mediated RNA methylation modification patterns in osteoarthritis.

ABSTRACT:

Background

Few studies have been reported the potential role of N6-methyladenosine (m⁶A) modification in osteoarthritis (OA). We investigated the patterns of m⁶A modification in the immune microenvironment of OA.

Methods

We evaluated the m⁶A modification patterns based on 22 m⁶A regulators in 139 OA samples and systematically associated these modification patterns with immune cell infiltration characteristics. The function of m⁶A phenotype-related differentially expressed genes (DEGs) was investigated using gene enrichment analysis. An m⁶A score model was constructed using principal component analysis (PCA), and an OA prediction model was established based on the key m⁶A regulators. We used real-tim

SUBMITTER: Ouyang Y 

PROVIDER: S-EPMC9728527 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature