PSMD2 promotes the progression of bladder cancer and is correlated with immune infiltration

ABSTRACT:

Introduction

PSMD2 plays an oncogenic role in multiple human malignancies, while it is still unclear that the potential roles and underlying mechanisms of PSMD2 in BCa.

Methods

The RNA-seq from TCGA and GTEx database was utilized to preliminarily analyze the expression of PSMD2 in BCa tissues, qRT-PCR was adopted to verify the PSMD2 expression in BCa cell lines. Cox regression analyses were applied to assess the prognostic values of PSMD2 in BCa. GSEA analysis was used to explore the underlying mechanisms of PSMD2. In vitro assays such as wound healing and colony formation assays were applied to determine the carcinogenesis of PSMD2 in BCa. xCell and ssGSEA algorithms were applied to analyze the associations of PSMD2 with TIME.

Results

The results revealed that i

SUBMITTER: Wang S 

PROVIDER: S-EPMC9728585 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature