Vasorelaxing properties of the perivascular tissue of the human radial artery.

ABSTRACT:

Objectives

Perivascular adipose tissue (PVAT) surrounding the human internal thoracic artery exhibits anticontractile and vasorelaxing properties associated with the adipocyte-derived relaxing factor (ADRF). The goal of our study was to assess if perivascular tissue of the human radial artery (RA) also exhibits such anticontractile/vasorelaxant properties. It could be especially relevant in preventing RA spasms.

Methods

The study was performed on isolated segments of human pedicled RA. Its skeletonized fragments were suspended on stainless steel wire hooks and gradually contracted with serotonin to establish the concentration-effect relationship in the presence/absence of PVAT. Skeletonized arterial segments were precontracted with a single dose of 10-6 M serotonin (EC80). T

SUBMITTER: Kociszewska K 

PROVIDER: S-EPMC9728790 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature