Optogenetic polymerization and assembly of electrically functional polymers for modulation of single-neuron excitability.

ABSTRACT: Ionic conductivity and membrane capacitance are two foundational parameters that govern neuron excitability. Conventional optogenetics has emerged as a powerful tool to temporarily manipulate membrane ionic conductivity in intact biological systems. However, no analogous method exists for precisely manipulating cell membrane capacitance to enable long-lasting modulation of neuronal excitability. Genetically targetable chemical assembly of conductive and insulating polymers can modulate cell membrane capacitance, but further development of this technique has been hindered by poor spatiotemporal control of the polymer deposition and cytotoxicity from the widely diffused peroxide. We address these issues by harnessing genetically targetable photosensitizer proteins to assemble electrically fu

SUBMITTER: Sessler CD 

PROVIDER: S-EPMC9728971 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature