Presynaptic contact and activity opposingly regulate postsynaptic dendrite outgrowth.

ABSTRACT: The organization of neural circuits determines nervous system function. Variability can arise during neural circuit development (e.g. neurite morphology, axon/dendrite position). To ensure robust nervous system function, mechanisms must exist to accommodate variation in neurite positioning during circuit formation. Previously, we developed a model system in the Drosophila ventral nerve cord to conditionally induce positional variability of a proprioceptive sensory axon terminal, and used this model to show that when we altered the presynaptic position of the sensory neuron, its major postsynaptic interneuron partner modified its dendritic arbor to match the presynaptic contact, resulting in functional synaptic input (Sales et al., 2019). Here, we investigate the cellular mechanisms

SUBMITTER: Heckman EL 

PROVIDER: S-EPMC9728994 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature