Quantifying the utility of islet autoantibody levels in the prediction of type 1 diabetes in children.

ABSTRACT:

Aims/hypothesis

The aim of this study was to explore the utility of islet autoantibody (IAb) levels for the prediction of type 1 diabetes in autoantibody-positive children.

Methods

Prospective cohort studies in Finland, Germany, Sweden and the USA followed 24,662 children at increased genetic or familial risk of developing islet autoimmunity and diabetes. For the 1403 who developed IAbs (523 of whom developed diabetes), levels of autoantibodies against insulin (IAA), glutamic acid decarboxylase (GADA) and insulinoma-associated antigen-2 (IA-2A) were harmonised for analysis. Diabetes prediction models using multivariate logistic regression with inverse probability censored weighting (IPCW) were trained using 10-fold cross-validation. Discriminative power for disease was estim

SUBMITTER: Ng K 

PROVIDER: S-EPMC9729160 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature