The effects of microglia on tauopathy progression can be quantified using Nexopathy in silico (Nexis) models.

ABSTRACT: The prion-like transsynaptic propagation of misfolded tau along the brain's connectome has previously been modeled using connectome-based network diffusion models. In addition to the connectome, interactions between the general neurological "milieu" in the neurodegenerative brain and proteinopathic species can also contribute to pathology propagation. Such a molecular nexopathy framework posits that the distinct characteristics of neurodegenerative disorders stem from interactions between the network and surrounding molecular players. However, the effects of these modulators remain unquantified. Here, we present Nexopathy in silico ("Nexis"), a quantitative model of tau progression augmenting earlier models by including parameters of pathology propagation defined by the molecular modulator

SUBMITTER: Anand C 

PROVIDER: S-EPMC9729195 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature