PTSD, major depression, and advanced transcriptomic age in brain tissue.

ABSTRACT:

Background

Psychiatric disorders have been associated with advanced epigenetic age in DNA methylation, yet this relationship has not been studied in the brain transcriptome. We examined transcriptomic age using an RNA-based algorithm recently developed by Ren and Kuan ("RNAAgeCalc") and the associations between posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and alcohol use disorder with age-adjusted RNA age ("RNA age residuals") in three brain regions: dorsolateral prefrontal cortex, ventromedial prefrontal cortex (vmPFC), and motor cortex.

Methods

RNA sequencing was used to measure gene expression in postmortem brain tissue from the VA National PTSD Brain Bank (n = 94; 59% male).

Results

Linear models revealed that diagnoses of PTSD and/or MDD

SUBMITTER: Zhao X 

PROVIDER: S-EPMC9729392 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature