Effects of age on the neural correlates of encoding source and item information: An fMRI study.

ABSTRACT: The effects of age on encoding-related neural activity predictive of accurate item and source memory judgments were examined with fMRI, with an a priori focus of the inferior frontal gyrus (IFG) and hippocampus. During a scanned study phase, young and older adults viewed a series of pictures of objects and made one of two judgments on each object. At test, which occurred outside of the scanner, an 'old/new' judgment on each test item was followed, for those items endorsed old, by a source judgment querying the study task. Neural activity predictive of accurate subsequent item and source memory judgments was identified in bilateral IFG, several other cortical regions and bilateral hippocampus. Cortical effects were graded in the young group (source > item > miss) but predicted item memory o

SUBMITTER: Liu ES 

PROVIDER: S-EPMC9729408 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature