Association between chemical mixtures and female fertility in women undergoing assisted reproduction in Sweden and Estonia.

ABSTRACT:

Objective

Women of reproductive age are exposed to ubiquitous chemicals such as phthalates, parabens, and per- and polyfluoroalkyl substances (PFAS), which have potential endocrine disrupting properties and might affect fertility. Our objective was to investigate associations between potential endocrine-disrupting chemicals (EDCs) and female fertility in two cohorts of women attending fertility clinics.

Methods

In a total population of 333 women in Sweden and Estonia, we studied the associations between chemicals and female fertility, evaluating ovarian sensitivity index (OSI) as an indicator of ovarian response, as well as clinical pregnancy and live birth from fresh and frozen embryo transfers. We measured 59 chemicals in follicular fluid samples and detected 3 phthalate m

SUBMITTER: Bellavia A 

PROVIDER: S-EPMC9729501 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature