Association between lipid metabolism and cognitive function in patients with schizophrenia

ABSTRACT:

Background

The association between blood lipids and cognitive function in schizophrenia is still controversial. Thus, the present study aimed to verify the association between various lipid parameters and cognitive impairment in schizophrenic patients and potential lipid pathways.

Methods

A total of 447 adult inpatients with schizophrenia were divided into cognitive normal and cognitive impairment groups based on the Mini-Mental State Examination with a cut-off of 26. The blood lipid parameters were defined as abnormal levels based on the guideline. The liquid chromatography-mass spectrometry method was used to preliminarily explore the potential lipid metabolism pathway associated with cognitive impairment.

Results

There were 368 (82.3%) patients who had cogniti

SUBMITTER: Liu H 

PROVIDER: S-EPMC9729695 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature