Gut microbiota signature as predictors of adverse outcomes after acute ischemic stroke in patients with hyperlipidemia.

ABSTRACT:

Introduction

The alterations of gut microbiota have been associated with multiple diseases. However, the relationship between gut microbiota and adverse outcomes of hyperlipidemic stroke patients remains unclear. Here we determined the gut microbial signature to predict the poor outcome of acute ischemic stroke (AIS) with hyperlipidemia (POAH).

Methods

Fecal samples from hyperlipidemic stroke patients were collected, which further analyzed by 16s rRNA gene sequencing. The diversity, community composition and differential gut microbiota were evaluated. The adverse outcomes were determined by modified Rankin Scale (mRS) scores at 3 months after admission. The diagnostic performance of microbial characteristics in predicting adverse outcomes was assessed by receiver operating c

SUBMITTER: Chen J 

PROVIDER: S-EPMC9729740 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature