Proteomic analysis of the chemosensitizing effect of curcumin on CRC cells treated with 5-FU.

ABSTRACT:

Background

5-Fluorouracil (5-FU) is one of the most common chemotherapy drugs used to treat colorectal cancer (CRC), which often develops resistance in more than 15% of patients. Curcumin, an active component of Curcuma longa, has been reported to show antitumor activity in CRC and, furthermore, enhance the effect of chemotherapy against colorectal cancer cells. However, the molecular mechanisms underlying the sensitizing effect of curcumin on 5-FU have not been largely elucidated. In this study, we aimed to systematically investigate the role of curcumin as a chemosensitizer for the treatment of CRC, along with the key events responsible for its pharmaceutical effect, which may lead to better clinical outcomes.

Methods

A high-resolution 2DE-based proteomics approach was use

SUBMITTER: Yang J 

PROVIDER: S-EPMC9729741 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature