Clinical Risk Factors For Kidney Tubule Biomarker Abnormalities Among Hypertensive Adults With Reduced eGFR in the SPRINT Trial.

ABSTRACT:

Background

Urine biomarkers of kidney tubule health may distinguish aspects of kidney damage that cannot be captured by current glomerular measures. Associations of clinical risk factors with specific kidney tubule biomarkers have not been evaluated in detail.

Methods

We performed a cross-sectional study in the Systolic Blood Pressure Intervention Trial among 2,436 participants with a baseline estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2. Associations between demographic and clinical characteristics with urine biomarkers of kidney tubule health were evaluated using simultaneous multivariable linear regression of selected variables.

Results

Each standard deviation higher age (9 years) was associated with 13% higher levels of chitinase-3-like protein-1

SUBMITTER: Ikeme JC 

PROVIDER: S-EPMC9729764 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature