Histologic healing and factors associated with complete remission following conventional treatment in ulcerative colitis.

ABSTRACT:

Background

Endoscopic and histological activity scores in ulcerative colitis (UC) are associated with clinical outcomes and have become important targets of clinical trials. However, these endpoints have been scarcely investigated in patients receiving only conventional treatment.

Objective

We aimed to assess the deep and complete remission rates after 3 months of conventional treatment in patients with newly diagnosed UC with moderate to severe endoscopic activity. We also aimed to investigate whether selected clinical and biochemical variables at baseline were associated with complete remission status after 3 months.

Design

This was a prospective cohort study.

Methods

Newly diagnosed patients with active UC commencing 5-aminosalicylate, corticosteroid, and/or

SUBMITTER: Steinsbo O 

PROVIDER: S-EPMC9729989 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature