High prevalence of heterogeneous mupirocin-resistant Staphylococcus aureus and its molecular characterization.

ABSTRACT:

Background

Mupirocin resistance of methicillin-resistant Staphylococcus aureus (MRSA) was frequently reported, but heterogeneous mupirocin resistance in Staphylococcus aureus (S. aureus) was rarely recognized. This study aims to investigate the prevalence of mupirocin heteroresistance among clinical S. aureus isolates and its possible molecular mechanism.

Methods

Disk diffusion and agar dilution were used to detect the resistance features of mupirocin resistant S. aureus isolates collected form a tertiary teaching hospital in China. Population analysis profiling was used to identify the mupirocin heteroresistant isolates. Multi locus sequence typing and Staphylococcus protein A gene molecular typing were used to discriminate the genetic features o

SUBMITTER: Mutu E 

PROVIDER: S-EPMC9730060 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature