Associations between NKX2-5 gene polymorphisms and congenital heart disease in the Chinese Tibetan population.

ABSTRACT:

Background

The pathogenesis of congenital heart disease (CHD) has not been fully elucidated, and this study considers the interaction between inheritance and the environment as the main cause of CHD. Previous studies have found that the incidence of CHD in the Tibetan plateau population is significantly higher than in low-altitude populations. Numerous reports have confirmed that NKX2-5 gene mutations can lead to coronary heart disease, but the relationship between NKX2-5 and Tibetan nationality has not yet been reported.

Objective

To explore the relationship between NKX2-5 gene polymorphisms and CHD in Tibetan people.

Methods

Blood samples were collected retrospectively from Tibetan patients diagnosed with CHD as well as healthy Tibetans, and the

SUBMITTER: Ma Q 

PROVIDER: S-EPMC9730064 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature