Prevalence of antibiotic resistance of Helicobacter pylori isolates in Shanghai, China.

ABSTRACT:

Objective

This study aimed to evaluate the resistance of Helicobacter pylori (H. pylori) to common antibiotics in Shanghai.

Methods

A total of 1171 eligible subjects participated in the study. Antibiotic susceptibility to six common antibiotics was examined with the disk diffusion method. Mutations in resistant-related genes were identified via Sanger sequencing analysis.

Results

Overall, the resistance rates of strains to amoxicillin, clarithromycin, levofloxacin, metronidazole, tetracycline, and furazolidone were 0.1%, 27.8%, 31.1%, 79.9%, 0.1%, and 0.5%, respectively. Compared with untreated patients, resistance rates of clarithromycin (P < 0.01), levofloxacin (P < 0.01), and metronidazole were significantly higher in re-treated patients (P<

SUBMITTER: Wang J 

PROVIDER: S-EPMC9730088 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature