A multidimensional approach to understanding the emergence of sex differences in internalizing symptoms in adolescence.

ABSTRACT: Women are more vulnerable to internalizing disorders (e.g., depression and anxiety). This study took an integrative developmental approach to investigate multidimensional factors associated with the emergence of sex differences in internalizing symptoms, using data from the Adolescent Brain Cognitive Development (ABCD) study. Indices of sex hormone levels (dehydroepiandrosterone, testosterone, and estradiol), physical pubertal development, task-based functional brain activity, family conflict, and internalizing symptoms were drawn from the ABCD study's baseline sample (9- to 10-year-old; N = 11,844). Principal component analysis served as a data-driven dimensionality reduction technique on the internalizing subscales to yield a single robust measure of internalizing symptoms. Moderated med

SUBMITTER: Serio B 

PROVIDER: S-EPMC9730154 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature