Landscape of the intratumroal microenvironment in bladder cancer: Implications for prognosis and immunotherapy.

ABSTRACT:

Introduction

This study aims to present the landscape of the intratumoral microenvironment and by which establish a classification system that can be used to predict the prognosis of bladder cancer patients and their response to anti-PD-L1 immunotherapy.

Methods

The expression profiles of 1554 bladder cancer cases were downloaded from seven public datasets. Single-sample gene set enrichment analysis (ssGSEA), univariate Cox regression analysis, and meta-analysis were employed to establish the bladder cancer immune prognostic index (BCIPI). Extensive analyses were executed to investigate the association between BCIPI and overall survival, tumor-infiltrated immunocytes, immunotherapeutic response, mutation load, etc.

Results

The results obtained from seven indepe

SUBMITTER: Bian Z 

PROVIDER: S-EPMC9730156 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature