Paternal transmission of behavioural and metabolic traits induced by postnatal stress to the 5th generation in mice.

ABSTRACT: Life experiences and environmental conditions in childhood can change the physiology and behaviour of exposed individuals and, in some cases, of their offspring. In rodent models, stress/trauma, poor diet, and endocrine disruptors in a parent have been shown to cause phenotypes in the direct progeny, suggesting intergenerational inheritance. A few models also examined transmission to further offspring and suggested transgenerational inheritance, but such multigenerational inheritance is not well characterized. Our previous work on a mouse model of early postnatal stress showed that behaviour and metabolism are altered in the offspring of exposed males up to the 4th generation in the patriline and up to the 2nd generation in the matriline. The present study examined if symptoms can be trans

SUBMITTER: Boscardin C 

PROVIDER: S-EPMC9730319 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature