Efficacy and safety of adalimumab for inflammatory flare prevention in paediatric non-infectious anterior uveitis with peripheral retinal vascular leakage: a study protocol for a single-centre, randomised controlled trial.

ABSTRACT:

Introduction

Paediatric patients with chronic anterior uveitis are more prone to suffer from the chronic course of intraocular inflammation and adverse effects of long-term immunomodulatory therapy, either topical glucocorticosteroids or systemic immunomodulatory agents. The performance of adalimumab has been shown to be fairly favourable in treating refractory non-infectious uveitis, but the detailed indication is still under investigation. This study aims to assess the efficacy and safety of adalimumab for inflammatory flare prevention in non-infectious paediatric anterior uveitis with peripheral retinal vascular leakage, compared with methotrexate.

Methods and analysis

Children weighed ≥30 kg and aged between 4 and 16 years old with active non-infectious anterior uveitis

SUBMITTER: Song H 

PROVIDER: S-EPMC9730384 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature